Anxiolytic effects of an aqueous extract of Crassocephalum bauchiense Hutch (Asteraceae) in mice with possible GABAergic involvement

Background and Objective: Crassocephalum bauchiense Hutch is a species of flowering plant from the Asteraceae family. It’s used in traditional medicine for treatment brain disorders including epilepsy, depression anxiety. This study evaluated anxiolytic effects aqueous extract its possible mechanism action. Materials Methods: The (25, 50, 100 200 mg/kg) were administered orally to mice one hour before behavioural testing. Elevated plus maze open field tests used, respectively detecting it properties. Immediately after test, animals sacrificed GABA content, activities GAD GABA-T measured. Results: (100 significantly increased number entries into, percentage time arms, reduced rearing, head dipping, closed elevated maze. crossing rearing defecation, test. In biochemical experiments, concentration activity increased; while was decreased, respectively, treated-mice. Conclusion: These results suggest that possess properties models employed. might potentially act by GABAergic activation central nervous system. data justify explain use treat anxiety empirically medicine.